Jurnal

Role of peroxisome proliferator-activated receptor gamma gene polymorphisms in type 2 diabetes mellitus patients of West Bengal, India

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Aims/Introduction: Peroxisome proliferator activated receptor gamma (PPARG) is a nuclear hormone receptor of the ligand-dependent transcription factor involved in adipogenesis, and a molecular target of the insulin sensitizer, thiazolidinediones. The present study aimed to investigate whether the PPARG gene is associated with type 2 diabetes mellitus and its related traits within the population of West Bengal, India. Materials and Methods: The study participants (200 type 2 diabetes mellitus and 200 normal individuals) were chosen randomly, and the variants were screened by direct sequencing. Results: The results showed that rs1801282 (odds ratio 0.66; 95% confidence interval 0.15–2.96; P = 0.57) and rs3856806 (odds ratio 1.23; 95% confidence interval 0.73–2.06; P = 0.44) variants of the PPARG gene were not associated with type 2 diabetes mellitus. Conclusions: The results showed that the PPARG gene was not associated with type 2 diabetesmellitus in our study population. As the lack of associationmight come from the small sample size, further studies with larger sample size are required to verify the present observation.

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Detail Information

Series Title

JDI Jurnal of Diabetes Investigation Volume 5, Issue 2 March 2014

Call Number

(05) 616.46 WIL j

Publisher

Australia : Wiley., 2014

Collation

Hlm. 188-191

Language

English

ISBN/ISSN

2040-1124

Classification

(05) 616.46 WIL j

Content Type

-

Media Type

-

Carrier Type

-

Edition

Volume 5, Issue 2

Subject(s)

Type 2 diabetes mellitus
Fasting sugar
Peroxisome proliferator activated receptor gamma g

Specific Detail Info

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